DNA fragments detected in monovalent and bivalent Pfizer/BioNTech and Moderna modRNA COVID-19 vaccines from Ontario, Canada: Exploratory dose response relationship with serious adverse events.
Overview
Paper Summary
This study found significant levels of DNA contamination in all 27 vials of Pfizer and Moderna mRNA COVID-19 vaccines tested. While below FDA guidelines when measured by qPCR, total DNA levels, measured by fluorometry, significantly exceeded recommended limits, potentially impacting safety. A preliminary analysis suggests a correlation between DNA levels and adverse events, warranting further investigation.
Explain Like I'm Five
Scientists found more DNA than expected in some COVID mRNA vaccines. While it's probably not enough to cause harm, it's more than regulations recommend, and it's unclear what effects it might have long term.
Possible Conflicts of Interest
One of the authors (K McKernan) is employed by Medicinal Genomics and provided the qPCR reagents free of charge. This potential conflict is disclosed in the paper.
Identified Limitations
Rating Explanation
The study presents important findings regarding DNA contamination in mRNA vaccines, but the small sample size, reliance on VAERS data, the correlational nature of the analysis, and the lack of mechanistic explanation warrant a cautious interpretation of the results and limit the overall rating to a 3.
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