Edge curvature drives endoplasmic reticulum reorganization and dictates epithelial migration mode
Overview
Paper Summary
This study reveals that the endoplasmic reticulum (ER), a network-like structure inside cells, changes shape depending on the curve of a wound edge, influencing how cells move to close it. At outward-curving edges, ER forms tubes and promotes crawling, while at inward-curving edges, it forms sheets and encourages tightening. This shape-shifting ER guides the orientation of cell-substrate attachments, thus controlling the migration mode.
Explain Like I'm Five
The way cells move to heal wounds depends on the shape of the wound edge. Cells at round edges grow finger-like projections, while cells at indented edges tighten up like a purse string.
Possible Conflicts of Interest
None identified.
Identified Limitations
Rating Explanation
This study provides strong evidence for a novel mechanism linking wound geometry to intracellular organization and cell migration. The combination of experimental and computational approaches, along with the use of multiple model systems, makes a compelling case for the role of the ER in dictating migration modes. Although further in vivo validation and exploration of broader cell type involvement are needed, the current findings significantly advance our understanding of wound healing.
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