Resistance training load does not determine resistance training-induced hypertrophy across upper and lower limbs in healthy young males
In healthy young men, this study found that muscle growth from resistance training is largely consistent within each person and unaffected by whether they lift heavy or light weights, as long as they train to muscle fatigue. While muscle protein synthesis rates were similar between loads, they decreased over the 10-week training period despite increasing training intensity. This suggests individual biological factors, not just the load, dictate how much muscle someone gains.